:root{--bg:#fff;--panel:#f7f8fa;--border:#dfe3e8;--text:#16191d;--muted:#6b7280;--accent:#1f5fa9;--warn-bg:#fdf3e3;--warn-text:#8a5a12;--assoc:#146b3a;--heat-hot:#c2410c;--heat-cold:#1d4ed8;--mono:ui-monospace, SFMono-Regular, "SF Mono", Menlo, monospace;--row:30px}@media (prefers-color-scheme:dark){:root{--bg:#101317;--panel:#171b21;--border:#2a3038;--text:#e6e9ee;--muted:#9099a6;--accent:#7fb0ea;--warn-bg:#33291a;--warn-text:#e0b467;--assoc:#5cc98d;--heat-hot:#f97316;--heat-cold:#60a5fa}}*{box-sizing:border-box}body{background:var(--bg);color:var(--text);margin:0;font:14px/1.45 -apple-system,BlinkMacSystemFont,Segoe UI,Helvetica,Arial,sans-serif}a{color:var(--accent);text-decoration:none}a:hover{text-decoration:underline}h2{margin:0 0 2px;font-size:19px}.muted{color:var(--muted)}.num{font-family:var(--mono);font-variant-numeric:tabular-nums;font-size:12.5px}.sym{font-family:var(--mono);font-size:12.5px}.right{text-align:right;justify-content:flex-end}.assoc{color:var(--assoc)}.synthetic-banner{background:var(--warn-bg);color:var(--warn-text);text-align:center;border-bottom:1px solid var(--border);padding:6px 16px;font-size:12.5px;font-weight:600}.app-head{border-bottom:1px solid var(--border);background:var(--panel);z-index:10;align-items:center;gap:16px;padding:10px 16px;display:flex;position:sticky;top:0}.brand{letter-spacing:.06em;color:var(--text);font-weight:700}.pheno{align-items:center;gap:6px;font-size:12px;display:flex}.app-head nav{gap:14px;margin-left:auto;display:flex}select,input,button{font:inherit;color:var(--text);background:var(--bg);border:1px solid var(--border);border-radius:6px;padding:5px 8px}button{cursor:pointer}main{padding:18px 16px 0}.status{color:var(--muted);padding:40px 16px}.status.error{color:#b91c1c}.gene-search{min-width:260px;position:relative}.gene-search input{width:100%}.typeahead{z-index:20;background:var(--bg);border:1px solid var(--border);border-radius:8px;max-height:320px;margin:0;padding:4px;list-style:none;position:absolute;top:110%;left:0;right:0;overflow:auto;box-shadow:0 8px 24px #0000001f}.typeahead button{text-align:left;background:0 0;border:0;border-radius:5px;align-items:center;gap:10px;width:100%;padding:5px 8px;display:flex}.typeahead button:hover{background:var(--panel)}.tag{background:var(--panel);color:var(--muted);border:1px solid var(--border);border-radius:999px;margin-left:8px;padding:1px 6px;font-size:11px;display:inline-block}.tag.warn{background:var(--warn-bg);color:var(--warn-text);border-color:#0000}.picker-head{flex-wrap:wrap;justify-content:space-between;gap:32px;display:flex}.picker-gene p{margin:0 0 4px;font-size:12px}.picker .search{width:320px;margin:14px 0 8px}table.baseline{border-collapse:collapse;width:100%;max-width:720px}table.baseline th,table.baseline td{border-bottom:1px solid var(--border);text-align:left;padding:5px 10px}table.baseline th{text-transform:uppercase;color:var(--muted);letter-spacing:.04em;font-size:11.5px}table.baseline tr.assoc td:first-child{font-weight:600}.view-head{margin-bottom:12px}.crumb{margin:0 0 2px;font-size:12px}.view-head p{margin:4px 0 0;font-size:12.5px}.controls{flex-wrap:wrap;align-items:center;gap:12px;margin-bottom:10px;display:flex}.controls .search{width:240px}.check{align-items:center;gap:6px;font-size:12.5px;display:flex}.btn{border:1px solid var(--border);border-radius:6px;padding:5px 10px}.segmented{display:flex}.segmented button{border-right-width:0;border-radius:0}.segmented button:first-child{border-radius:6px 0 0 6px}.segmented button:last-child{border-right-width:1px;border-radius:0 6px 6px 0}.segmented button.on{background:var(--accent);color:#fff;border-color:var(--accent)}.table-wrap{border:1px solid var(--border);border-radius:8px;overflow:hidden}.table-head{background:var(--panel);border-bottom:1px solid var(--border);display:grid}.th{text-transform:uppercase;letter-spacing:.04em;color:var(--muted);text-align:left;background:0 0;border:0;border-radius:0;align-items:center;gap:5px;padding:7px 10px;font-size:11.5px;display:flex}.th.right{justify-content:flex-end}.th:not(.static):hover{color:var(--text);background:var(--border)}.th.static{cursor:default}.arrow{font-size:8px}.table-body{height:calc(100vh - 300px);min-height:320px;overflow:auto}.tr{border-bottom:1px solid var(--border);width:100%;color:var(--text);align-items:center;display:grid;position:absolute;top:0;left:0}.tr:hover{background:var(--panel)}.tr:hover .sym{text-decoration:underline}.tr.untested{opacity:.5}.td{text-overflow:ellipsis;white-space:nowrap;padding:0 10px;overflow:hidden}.td.right{text-align:right}.table-foot{color:var(--muted);border-top:1px solid var(--border);background:var(--panel);padding:6px 10px;font-size:12px}.empty{color:var(--muted);padding:32px}.builder{max-width:860px}.builder fieldset{border:1px solid var(--border);border-radius:8px;margin:14px 0;padding:10px 14px 14px}.builder legend{text-transform:uppercase;letter-spacing:.05em;color:var(--muted);padding:0 6px;font-size:12px}.builder .hint{color:var(--muted);margin:0 0 8px;font-size:12.5px}.builder .row{flex-wrap:wrap;align-items:center;gap:16px;display:flex}.builder fieldset.off{opacity:.45}.check.disabled,label.disabled{opacity:.5}.summary{border-top:1px solid var(--border);flex-direction:column;align-items:flex-start;gap:10px;padding-top:14px;display:flex}.summary p{margin:0}.summary code{font-family:var(--mono);background:var(--panel);border:1px solid var(--border);white-space:nowrap;border-radius:6px;width:100%;padding:6px 9px;font-size:11.5px;overflow-x:auto}.btn.primary{background:var(--accent);color:#fff;border-color:var(--accent)}.advanced{border:1px solid var(--border);background:var(--panel);border-radius:8px;margin-bottom:10px}.advanced summary{cursor:pointer;color:var(--muted);-webkit-user-select:none;user-select:none;align-items:center;gap:8px;padding:7px 12px;font-size:12.5px;display:flex}.advanced summary:hover{color:var(--text)}.advanced[open] summary{border-bottom:1px solid var(--border)}.badge{background:var(--accent);color:#fff;border-radius:999px;padding:0 6px;font-size:10.5px;font-weight:700;line-height:16px}.advanced-body{flex-wrap:wrap;align-items:flex-start;gap:20px;padding:12px;display:flex}.field{flex-direction:column;flex:320px;gap:4px;display:flex}.field.narrow{flex:0 0 150px}.field>span:first-child{text-transform:uppercase;letter-spacing:.04em;color:var(--muted);font-size:11.5px}.field-note{color:var(--muted);min-height:15px;font-size:11.5px}.field-note .bad{color:#d97706}.link-btn{color:var(--accent);background:0 0;border:0;align-self:flex-end;margin-bottom:18px;padding:0;font-size:12.5px}.synthetic-banner.warn{background:var(--warn-bg);color:var(--warn-text)}.study-label{color:var(--muted);align-items:center;gap:6px;font-size:12.5px;display:flex}.pheno select{max-width:22rem}.td.num{text-overflow:clip}.table-body,.table-head{min-width:max-content}.table-wrap{overflow-x:auto}