:root{--bg:#fff;--ink:#101114;--ink-soft:#5c6067;--ink-faint:#91959c;--rule:#d7d9dd;--rule-soft:#eef0f2;--link:#14459b;--sig:#0f6b33;--warn:#8a4b00;--mono:ui-monospace, SFMono-Regular, "SF Mono", Menlo, monospace;--row:26px}*{box-sizing:border-box}body{background:var(--bg);color:var(--ink);margin:0;font:14px/1.5 -apple-system,BlinkMacSystemFont,Segoe UI,Helvetica,Arial,sans-serif}a{color:var(--link);text-decoration:none}a:hover{text-decoration:underline}h2{letter-spacing:-.02em;margin:0;font-size:22px;font-weight:600}h3{font-size:11px}p{margin:0}.muted{color:var(--ink-soft)}.num{font-family:var(--mono);font-variant-numeric:tabular-nums;font-size:12px}.sym{font-family:var(--mono);font-size:12px}.right{text-align:right;justify-content:flex-end}.assoc{color:var(--sig)}input,select,button{font:inherit;color:var(--ink);background:var(--bg);border:1px solid var(--rule);border-radius:0;padding:3px 6px}button{cursor:pointer}input[type=checkbox],input[type=radio]{accent-color:var(--ink-soft)}.synthetic-banner{color:var(--warn);border-bottom:1px solid var(--rule);padding:5px 20px;font-size:12px}.app-head{border-bottom:1px solid var(--rule);align-items:baseline;gap:18px;padding:12px 20px;display:flex}.brand{letter-spacing:.04em;color:var(--ink);font-size:13px;font-weight:600}.pheno{align-items:baseline;display:flex}.study-label{color:var(--ink-soft);gap:8px;font-size:12px;display:flex}main{padding:20px}.status{color:var(--ink-soft);padding:40px 20px}.status.error{color:#a11}.gene-search{min-width:240px;position:relative}.gene-search input{width:100%}.typeahead{z-index:20;background:var(--bg);border:1px solid var(--rule);border-top:0;max-height:300px;margin:0;padding:0;list-style:none;position:absolute;top:100%;left:0;right:0;overflow:auto}.typeahead button{text-align:left;background:0 0;border:0;align-items:baseline;gap:10px;width:100%;padding:4px 8px;display:flex}.typeahead button:hover{background:var(--rule-soft)}.tag{color:var(--ink-soft);font-size:12px}.view-head .tag{margin-left:10px}.tag.warn{color:var(--warn)}.picker-head h2{margin-bottom:3px}.picker h2{margin-bottom:10px}table.baseline{border-collapse:collapse;width:100%;max-width:640px}table.baseline th,table.baseline td{border-bottom:1px solid var(--rule-soft);text-align:left;padding:4px 12px 4px 0}table.baseline th.right,table.baseline td.right{text-align:right}table.baseline th{text-transform:uppercase;letter-spacing:.08em;color:var(--ink-faint);border-bottom-color:var(--rule);font-size:10.5px;font-weight:500}.view-head{margin-bottom:14px}.title-row{align-items:baseline;gap:14px;display:flex}.crumb{font-size:12px}.view-head p{margin-top:3px;font-size:12px}.controls{flex-wrap:wrap;align-items:baseline;gap:18px;margin-bottom:16px;display:flex}.controls .search{width:220px}.check{align-items:baseline;gap:5px;font-size:12px;display:flex}.btn{color:var(--link)}.segmented{gap:10px;font-size:12px;display:flex}.segmented button{color:var(--ink-soft);background:0 0;border:0;padding:0}.segmented button.on{color:var(--ink);text-underline-offset:3px;text-decoration:underline}.table-wrap{overflow-x:auto}.table-head{border-bottom:1px solid var(--rule);min-width:max-content;display:grid}.th{text-transform:uppercase;letter-spacing:.08em;color:var(--ink-faint);text-align:left;background:0 0;border:0;align-items:baseline;gap:4px;padding:5px 12px 5px 0;font-size:11px;font-weight:500;display:flex}.th.right{justify-content:flex-end}.th:not(.static):hover{color:var(--ink)}.th.static{cursor:default}.arrow{font-size:8px}.table-body{min-width:max-content;height:calc(100vh - 260px);min-height:300px;overflow:auto}.tr{border-bottom:1px solid var(--rule-soft);width:100%;color:var(--ink);align-items:center;display:grid;position:absolute;top:0;left:0}.tr:hover{background:var(--rule-soft)}.tr.untested{color:var(--ink-soft)}.td{white-space:nowrap;padding:0 12px 0 0;overflow:hidden}.td:nth-child(2){color:var(--ink);font-weight:500}.td.rank{color:var(--ink-faint);font-size:11px}.td.right{text-align:right}.td.num{text-overflow:clip}.table-foot{color:var(--ink-soft);border-top:1px solid var(--rule);padding:6px 0;font-size:12px}.empty{color:var(--ink-soft);padding:30px 0}.advanced{margin-bottom:12px}.advanced summary{cursor:pointer;color:var(--ink-soft);-webkit-user-select:none;user-select:none;padding:2px 0;font-size:12px}.advanced summary:hover,.badge{color:var(--ink)}.advanced-body{border-bottom:1px solid var(--rule-soft);flex-wrap:wrap;align-items:flex-start;gap:24px;padding:10px 0 4px;display:flex}.field{flex-direction:column;flex:300px;gap:3px;display:flex}.field.narrow{flex:0 0 140px}.field>span:first-child{text-transform:uppercase;letter-spacing:.06em;color:var(--ink-soft);font-size:11px}.field-note{color:var(--ink-soft);min-height:14px;font-size:11px}.field-note .bad{color:var(--warn)}.link-btn{color:var(--link);background:0 0;border:0;align-self:flex-end;margin-bottom:16px;padding:0;font-size:12px}.builder fieldset{border:0;border-top:1px solid var(--rule-soft);margin:0 0 4px;padding:12px 0}.builder legend{text-transform:uppercase;letter-spacing:.06em;color:var(--ink-soft);padding:0;font-size:11px}.builder .hint{color:var(--ink-soft);margin-bottom:8px;font-size:12px}.builder .row{flex-wrap:wrap;align-items:baseline;gap:16px;display:flex}.builder fieldset.off{opacity:.45}.check.disabled,label.disabled{color:var(--ink-soft)}.summary{border-top:1px solid var(--rule);margin-top:8px;padding-top:12px}.summary code{font-family:var(--mono);color:var(--ink-soft);word-break:break-all;margin:8px 0;font-size:11px;display:block}.btn.primary{color:var(--link)}.landing{max-width:660px}.landing h2{margin-bottom:10px}.landing h3{text-transform:uppercase;letter-spacing:.06em;color:var(--ink-soft);margin:0 0 8px;font-size:13px;font-weight:600}.prose p{margin-bottom:8px}.prose p:last-child{margin-bottom:0}.small{font-size:12px}.landing dl{margin:0}.landing dt{font-family:var(--mono);margin-top:10px;font-size:12px}.landing dd{color:var(--ink-soft);margin:2px 0 0}table.studies{max-width:100%}table.studies th[scope=row]{color:var(--ink-soft);width:15rem;font-weight:400}.study-entry{margin-right:16px}.panel{border:1px solid var(--rule);margin-bottom:22px;padding:14px 16px}.panel>h3{text-transform:uppercase;letter-spacing:.08em;color:var(--ink-faint);margin:0 0 10px;font-size:10.5px;font-weight:500}.view-head{margin-bottom:4px;padding-bottom:18px}.dist{margin:0}.dist svg{width:100%;height:auto;display:block}.dist .tick{font-family:var(--mono);fill:var(--ink-soft);font-size:9px}.dist figcaption{margin-top:4px}.dist rect{transition:fill 80ms linear}.cutoff{flex-wrap:wrap;align-items:baseline;gap:10px;margin-bottom:10px;font-size:12px;display:flex}.link-btn.inline{align-self:baseline;margin:0}.link-btn.inline.on{color:var(--ink);text-underline-offset:3px;text-decoration:underline}.typeahead ul{margin:0;padding:0;list-style:none}.typeahead-head{text-transform:uppercase;letter-spacing:.06em;color:var(--ink-soft);border-top:1px solid var(--rule-soft);padding:5px 8px 2px;font-size:10px}.typeahead>div:first-child .typeahead-head{border-top:0}.th.right.static{color:var(--ink-faint)}.panel>h3{align-items:baseline;gap:10px;display:flex}.btn-solid{border:1px solid var(--rule);background:var(--bg);color:var(--ink);white-space:nowrap;padding:3px 10px;font-size:14px}.btn-solid:hover{border-color:var(--ink-soft);text-decoration:none}.builder .row .check{align-items:flex-start;max-width:22rem}.picker-table{max-width:720px}.picker-table td{padding-top:5px;padding-bottom:5px}.picker-table .rank{width:3rem;color:var(--ink-faint);font-size:11px}.picker-table .se,.picker-table tr.weak td:not(.assoc),.picker-table tr.weak a{color:var(--ink-soft)}.picker-table tr.boundary td{border-bottom:1px solid var(--ink-soft);border-top:1px solid var(--ink-soft);text-transform:uppercase;letter-spacing:.08em;color:var(--ink-soft);padding:6px 0;font-size:11px}.picker .panel{padding:4px 16px 8px;display:inline-block}.picker-table{min-width:620px}